The study found that the incidence of symptomatic relapse was higher in the amoxicillin group than in the first-generation cephalosporin group. The Infectious Disease Society maintains in its guidelines that amoxicillin is the first choice for group A streptococcal pharyngitis.
Cephalexin is an acceptable alternative for patients with a penicillin-related allergy. Cephalexin is a prescription medication that is covered by both commercial and Medicare drug insurance plans. A typical prescription for cephalexin would be written for 28 capsules of the mg strength. Amoxicillin is a prescription medication that is also covered by both commercial and Medicare drug insurance plans.
Get the SingleCare prescription discount card. Cephalexin and amoxicillin have a similar list of side effects. The most common side effect of both medications is diarrhea. Other gastrointestinal side effects include nausea, vomiting, and gastritis. In rare instances, cases of pseudomembranous colitis have been reported.
Anaphylactic reactions may happen with both cephalexin and amoxicillin. Anaphylactic reactions require immediate medical attention. The following list is not intended to be a complete list of possible side effects. Please consult a pharmacist, doctor, or another medical professional for a complete list of possible side effects. Cephalexin may increase the serum concentrations of the common antidiabetic agent metformin.
Most courses of cephalexin are a short duration, so the drugs may be used concurrently as long as the patient is monitored. Amoxicillin may interfere with the serum concentrations of important immunosuppressants. Serum concentrations of methotrexate have been shown to be increased with concurrent use with amoxicillin, while mycophenolate concentrations may be decreased.
These immunosuppressant drugs are used in patients with serious conditions, and therefore patients who require the use of amoxicillin while on these drugs should be monitored closely. Probenecid , when given with cephalexin or amoxicillin, may increase the serum concentrations of either antibiotic. While the use of both at the same time is not contraindicated, patients should be monitored.
Patients with a penicillin allergy should not take amoxicillin. There is evidence to suggest that patients with a penicillin allergy may also have a cross-sensitivity to cephalosporins, including cephalexin. Caution should be used when prescribing cephalexin in penicillin-allergic patients with no prior use of cephalosporins.
Pseudomembranous colitis is a rare but serious condition. It involves the swelling and inflammation of the colon due to an overgrowth of clostridium difficile. Pseudomembranous colitis can occur with a variety of antibiotics, including cephalexin and amoxicillin. Cephalexin and amoxicillin are renally excreted. Patients with decreased or impaired renal function must have their doses adjusted accordingly. Cephalexin is considered pregnancy category B, meaning that animal studies have not shown any teratogenic effects.
It is considered generally safe in pregnancy. Cephalexin crosses into breast milk but is generally considered safe while breastfeeding. Amoxicillin is also considered pregnancy category B.
Amoxicillin crosses into breast milk but is also considered safe while breastfeeding. Cephalexin is a first-generation, cephalosporin antibiotic. It belongs to a bigger classification of antibiotics known as beta-lactam antibiotics. It is generally effective against bacteria involved in upper and lower respiratory tract infections, otitis media, mastitis, and skin, bone, and joint infections. After treatment, the majority of patients demonstrated an increase in paired antistreptolysin-O and anti-DNase beta titers.
At follow-up, treatment of recurrences with the other medication were successful in about 85 percent of cases, but did not suggest that either drug was better. This study supports other research indicating that cephalosporins are excellent for treating group A streptococcal infections and may surpass penicillin.
The increased cost of cephalexin must be weighed against the cost of possible retreatment when choosing penicillin. This study was supported by a manufacturer of cephalexin Keflex.
Disney FA et al. Cephalexin and penicillin in the treatment of group A beta hemolytic streptococcal throat infections. Am J Dis Child Nov Am J Dis Child Nov Penicillin, the old standard antibiotic for treating group A streptococcal infections, has become less effective because of higher failure and recurrence rates.
Participants: Of the patients, children and adolescents with clinical evidence of tonsillitis or pharyngitis and throat cultures positive for group A beta-hemolytic streptococcal infection were evaluable.
Eighty percent of patients completed the study; none were withdrawn because of adverse reaction. Selection criteria: Children and adolescents who had acute illness suggestive of group A beta-hemolytic streptococcal infection were enrolled in the study. Treatment was continued if the throat culture was positive for group A beta-hemolytic streptococcal infection.
0コメント